Beta Thalassemia Trait: Current status of India

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A. Dubey
Kiranmala Devi N.
R. Deb

Abstract

The genetic disorders of hemoglobin, particularly the β-thalassemias is a considerable health problem in India and contribute significantly to morbidity and mortality (Sur, et. al. 2016). Beta thalassemia is the most common inherited monogenic disorder. India forms a major part of the thalassemia belt in the world (Saha, et. al. 2020). The different types of thalassemia include minor, major and intermedia, based on the α/β-globin chain inequality (Yadav, et. al. 2022). This review aims to outline the Beta thalassemia carrier status in India. For gathering the data articles reporting the prevalence of Beta thalassemia in various regions of India were reviewed. In total, 17 articles were reviewed through SCOPUS and PubMed database from 2011 to 2022. The search criteria included articles in only English language, studies from India and duplicate articles were removed. The studies from other countries and including genetic and molecular characterisation were excluded. The review of studies found that Kota (Rajasthan) had the highest rate of beta thalassemia trait (48.76%), while Odisha had the lowest prevalence at 0.07%. (Bhattacharya et al., 2016; Dixit et al., 2022). The cost of treating Beta thalassemia is very high and not affordable by many Indians. Thus, it becomes very important to reduce the number of carriers. In India, screening for the detection of carriers in an annual cohort of adolescents in schools and/or of all pregnant women is the most feasible prevention strategy available for reducing the birth of children affected with thalassaemia (Sinha, et. al. 2020). 

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How to Cite
Dubey, A., Kiranmala Devi, N., & Deb, R. (2023). Beta Thalassemia Trait: Current status of India. International Journal of Anthropology, 38(3-4), 203-215. https://doi.org/10.14673/IJA2023341110
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