Exploring the role of PTC with various health related issues and susceptible diseases

Abstract

Background — Sensitivity to phenylthiocarbamide (PTC) varies between individuals and populations. People carrying at least one dominant allele (TT or Tt) can usually detect PTC, while those with two recessive alleles (tt) typically cannot.
Methods — A cross-sectional study involved 282 adults (132 Koch, 150 Karbi) aged over 18 years. Participants’ demographic data and self-reported health conditions, confirmed through medical prescriptions, were collected.
Results — Non tasters were more frequent among diabetic Koch participants (53.3%), whereas diabetic Karbi participants were predominantly tasters (75%). Tasters were more common across blood pressure categories (Koch: 62.5%; Karbi: 72.7%). Tasters also reported higher incidences of thyroid disorders, goitre, and throat ailments, particularly among the Koch.
Conclusion — PTC tasting ability was not significantly associated with health conditions. Nevertheless, tasters appeared more susceptible to certain infectious diseases, including malaria and jaundice, suggesting potential links between taste sensitivity and disease susceptibility.